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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES3
All Species:
1.82
Human Site:
S180
Identified Species:
4
UniProt:
Q5TGS1
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5TGS1
NP_001019769.1
186
19968
S180
R
V
W
R
P
W
G
S
P
G
D
D
L
N
_
Chimpanzee
Pan troglodytes
XP_001162588
239
25232
P184
G
F
Q
V
V
P
A
P
D
G
Q
F
A
F
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546749
200
21060
Cat
Felis silvestris
Mouse
Mus musculus
Q61657
175
19275
Rat
Rattus norvegicus
Q04667
175
19118
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511924
287
29320
G207
G
G
G
G
G
G
G
G
P
V
P
C
K
L
G
Chicken
Gallus gallus
O57337
290
31053
F223
F
L
I
P
N
P
A
F
P
P
G
S
G
P
V
Frog
Xenopus laevis
Q8AVU4
267
28644
P225
F
A
F
L
I
T
N
P
A
F
P
Q
N
G
S
Zebra Danio
Brachydanio rerio
Q9I9L0
324
34311
S234
D
S
A
L
R
A
P
S
T
G
S
V
A
P
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
M228
S
G
E
F
A
L
I
M
P
N
T
G
S
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001175739
383
41428
S319
L
S
N
I
P
S
L
S
P
S
T
P
V
V
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28
N.A.
67
N.A.
65.5
63.9
N.A.
25.7
24.1
25.8
22.5
N.A.
20.9
N.A.
N.A.
21.9
Protein Similarity:
100
39.7
N.A.
70
N.A.
70.4
72
N.A.
35.8
36.2
35.9
33.3
N.A.
29.6
N.A.
N.A.
31.3
P-Site Identity:
100
6.6
N.A.
0
N.A.
0
0
N.A.
13.3
6.6
0
13.3
N.A.
6.6
N.A.
N.A.
20
P-Site Similarity:
100
6.6
N.A.
0
N.A.
0
0
N.A.
20
13.3
6.6
13.3
N.A.
6.6
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
10
10
19
0
10
0
0
0
19
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% C
% Asp:
10
0
0
0
0
0
0
0
10
0
10
10
0
0
0
% D
% Glu:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
19
10
10
10
0
0
0
10
0
10
0
10
0
10
0
% F
% Gly:
19
19
10
10
10
10
19
10
0
28
10
10
10
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
10
10
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% K
% Leu:
10
10
0
19
0
10
10
0
0
0
0
0
10
10
19
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
10
0
10
0
0
10
0
0
10
10
0
% N
% Pro:
0
0
0
10
19
19
10
19
46
10
19
10
0
19
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
10
10
0
0
0
% Q
% Arg:
10
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
19
0
0
0
10
0
28
0
10
10
10
10
0
10
% S
% Thr:
0
0
0
0
0
10
0
0
10
0
19
0
0
0
0
% T
% Val:
0
10
0
10
10
0
0
0
0
10
0
10
10
10
10
% V
% Trp:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% _